Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat
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چکیده
منابع مشابه
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat.
BACKGROUND AND AIMS Inflammatory bowel disease is characterised by oxidative and nitrosative stress, leucocyte infiltration, upregulation of expression of intercellular adhesion molecule 1 (ICAM-1), and upregulation of P-selectin in the colon. The aim of the present study was to examine the effects of calpain inhibitor I in rats subjected to experimental colitis. METHODS Colitis was induced i...
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Objective(s): Gold nanoparticles (GNPs) command a great deal of attention for biomedical applications nowadays. The data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge. Materials and Methods: A total of 32 healthy male Wistar rats were randomly divided into 4 including: three GNP-treated and one control group. Groups 1, 2 and 3 receive...
متن کاملthe acute liver injury in rat caused by gold nanoparticles
objective(s): gold nanoparticles (gnps) command a great deal of attention for biomedical applications nowadays. the data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge. materials and methods: a total of 32 healthy male wistar rats were randomly divided into 4 including: three gnp-treated and one control group. groups 1, 2 and 3 receive...
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Marked increases in intracellular calcium may play a role in mediating cellular dysfunction and death following central nervous system trauma, in part through the activation of the calcium-dependent neutral protease calpain. In this study, we evaluated the effect of the calpain inhibitor AK295 [Z-Leu-aminobutyric acid-CONH(CH2)3-morpholine] on cognitive and motor deficits following lateral flui...
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ژورنال
عنوان ژورنال: Gut
سال: 2001
ISSN: 0017-5749
DOI: 10.1136/gut.48.4.478